IVV (in vitro virus) method
Single cell transcriptome analysis
Publications
GVHD：
- Shono, Y. et al., Blood, 115: 5401-5411 (2010).
Link: https://www.ncbi.nlm.nih.gov/pubmed/20354171 - Ueha, S. et al., Cancer Sci., 108: 1967-1973 (2017).
Link: https://www.ncbi.nlm.nih.gov/pubmed/28787768 - Ni, X. et al., J. Clin. Invest., 127: 1960-1977 (2017).
Link: https://www.ncbi.nlm.nih.gov/pubmed/28414296
Solid Tumors：
- Ueha, S. et al., Cancer Immunol. Res., 3: 631-640 (2015).
Link: https://www.ncbi.nlm.nih.gov/pubmed/25711759
| Conference | Date | Title | Authors |
|---|---|---|---|
| 73rd Annual Meeting of the Japanese Cancer Association | 27-Sep-2014 | Synergistic anti-tumor effect of CD4 depleting antibody with immune checkpoi nt antibodies in murine tumor models | Ueha1, Satoshi1. Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1 1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital |
| 73rd Annual Meeting of the Japanese Cancer Association | 10-Dec-2014 | Administration of anti-CD4 depleting antibody together with anti-PD-1/anti-PD-L1 antibody shows dramatic anti-tumor effects in mice | Y. Ishiwata1,2, S. Yokochi2, K. Kakimi3, S. Ueha1, S. Ito2, K. Matsushima1 1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital |
| 73rd Annual Meeting of the Japanese Cancer Association | 10-Dec-2014 | Loss of Lympho node fibroblastic reticular cells and high endothelial cells underlies humoral Immunomodeficiency in mouse GVHD | Ueha1, Satoshi1. Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1 1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital |
| The AACR Annual Meeting | 19-Apr-2015 | Robust anti-tumor effects of combined anti-CD4 depleting antibody and anti-PD-1/PD-L1 immune checkpoint antibody treatment in mice | Satoru Ito1,2, Satoshi Ueha1, Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Kosuke Hachiga1,2, Haru Ogiwara1, Krishant Chand1 , Takumi Nakajima1, Kazuhiro Kakimi3, Kouji Matsushima1 Dep. of Molecular Preventive Medicine, Graduate School of Medicine, The Univ. of Tokyo; 2:IDAC Theranostics, Inc. , 3:Dep. of Immunotherapeutics, The Univ. of Tokyo Hospital |
| ICCIM2015 | 9-Jul-2015 | Amelioration of GVHD maintaining GVT effect on allo-HSCT by depletion of donor CD4+ T cells in solid-tumor bearing mouse model | Ueha1, Satoshi1. Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1 1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital |
| 74th Annual Meeting of the Japanese Cancer Association 10-Oct-2015 | 10-Oct-2015 | Suppression of tumor metastasis in 4T1 breast cancer model with anti-CD4 monoclonal antibody treatment | Shoji Yokochi1, Satoshi Ueha2, Yoshiro Ishiwata1, Satoru Ito1, Kouji Matsushima2 1 IDAC Theranostics, Inc., Tokyo, Japan; 2 The University of Tokyo, Tokyo, Japan |
| 74th Annual Meeting of the Japanese Cancer Association | 10-Oct-2015 | Robust anti-tumor effects of combined anti-CD4 depleting antibody and snti-PD-L1 antibody treatment in mice | Ueha1, Satoshi1. Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1 1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital |
| 44th Annual Meeting of the Japanese Society for Immunology | 19-Nov-2015 | Anti-CD4 depleting mAb administration improves costimulatory signals and cytokine microenvironments in the tumor draining lympho node | Ueha1, Satoshi1. Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1 1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital |
| American Association for Cancer Reseach | 2016.4.2017 | An anti-CD4 antibody protects mice from anti-PD-1/PD-L1 antibody-induced fatal anaphylaxis and shows potent anti-metastatic activity in the 4T1 spontaneous metastasis model | Satoru Ito1,2, Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoshi Ueha1, Francis Shand1, Kouji Matsushima1 Dep. of Molecular Preventive Medicine, Graduate School of Medicine, The Univ. of Tokyo; 2:IDAC Theranostics, Inc. |