Technology

IVV (in vitro virus) method

 

Single cell transcriptome analysis

 

Publications

GVHD:
  1. Shono, Y. et al., Blood, 115: 5401-5411 (2010).
    Link: https://www.ncbi.nlm.nih.gov/pubmed/20354171
  2. Ueha, S. et al., Cancer Sci., 108: 1967-1973 (2017).
    Link: https://www.ncbi.nlm.nih.gov/pubmed/28787768
  3. Ni, X. et al., J. Clin. Invest., 127: 1960-1977 (2017).
    Link: https://www.ncbi.nlm.nih.gov/pubmed/28414296

 

Solid Tumors:
  1. Ueha, S. et al., Cancer Immunol. Res., 3: 631-640 (2015).
    Link: https://www.ncbi.nlm.nih.gov/pubmed/25711759

 

Conference Date Title Authors
73rd Annual Meeting of the Japanese Cancer Association 27-Sep-2014 Synergistic anti-tumor effect of CD4 depleting antibody with immune checkpoi nt antibodies in murine tumor models Ueha1, Satoshi1.  Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1
1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital
73rd Annual Meeting of the Japanese Cancer Association 10-Dec-2014 Administration of anti-CD4 depleting antibody together with anti-PD-1/anti-PD-L1 antibody shows dramatic anti-tumor effects in mice  Y. Ishiwata1,2, S. Yokochi2, K. Kakimi3, S. Ueha1, S. Ito2, K. Matsushima1
1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital
73rd Annual Meeting of the Japanese Cancer Association 10-Dec-2014 Loss of Lympho node fibroblastic reticular cells and high endothelial cells underlies humoral Immunomodeficiency in mouse GVHD Ueha1, Satoshi1.  Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1
1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital
The AACR Annual Meeting 19-Apr-2015 Robust anti-tumor effects of combined anti-CD4 depleting antibody and anti-PD-1/PD-L1 immune checkpoint antibody treatment in mice  Satoru Ito1,2, Satoshi Ueha1, Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Kosuke Hachiga1,2, Haru Ogiwara1, Krishant Chand1 , Takumi Nakajima1, Kazuhiro Kakimi3, Kouji Matsushima1
Dep. of Molecular Preventive Medicine, Graduate School of Medicine, The Univ. of Tokyo; 2:IDAC Theranostics, Inc. , 3:Dep. of Immunotherapeutics, The Univ. of Tokyo Hospital
ICCIM2015 9-Jul-2015 Amelioration of GVHD maintaining GVT effect on allo-HSCT by depletion of donor CD4+ T cells in solid-tumor bearing mouse model Ueha1, Satoshi1.  Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1
1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital
74th Annual Meeting of the Japanese Cancer Association  10-Oct-2015 10-Oct-2015 Suppression of tumor metastasis in 4T1 breast cancer model with anti-CD4 monoclonal antibody treatment Shoji Yokochi1, Satoshi Ueha2, Yoshiro Ishiwata1, Satoru Ito1, Kouji Matsushima2
1 IDAC Theranostics, Inc., Tokyo, Japan; 2 The University of Tokyo, Tokyo, Japan
74th Annual Meeting of the Japanese Cancer Association 10-Oct-2015 Robust anti-tumor effects of combined anti-CD4 depleting antibody and snti-PD-L1 antibody treatment in mice Ueha1, Satoshi1.  Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1
1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital
44th Annual Meeting of the Japanese Society for Immunology 19-Nov-2015 Anti-CD4 depleting mAb administration improves costimulatory signals and cytokine microenvironments in the tumor draining lympho node Ueha1, Satoshi1.  Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoru Ito1,2, Yuya Terashima1, Kazuhiro Kakimi3, Matsushima1
1) The Department of Molecular Preventive Medicine, The University of Tokyo, 2) IDAC Theranostics, Inc. 3) The Department of Immunotherapeutics, The University of Tokyo Hospital
American Association for Cancer Reseach 2016.4.2017 An anti-CD4 antibody protects mice from anti-PD-1/PD-L1 antibody-induced fatal anaphylaxis and shows potent anti-metastatic activity in the 4T1 spontaneous metastasis model Satoru Ito1,2, Shoji Yokochi1,2, Yoshiro Ishiwata1,2, Satoshi Ueha1, Francis Shand1, Kouji Matsushima1
Dep. of Molecular Preventive Medicine, Graduate School of Medicine, The Univ. of Tokyo; 2:IDAC Theranostics, Inc.